Gene therapy for ischaemic heart disease and heart failure
نویسندگان
چکیده
منابع مشابه
Gene Therapy for Heart Failure
Heart failure is an important public medical problem in the developed countries. Although there are numerous and fascinating medicines given by physicians for the treatment of heart failure, the general 5 year survival rate for advanced heart failure is only about 50%. There are still many theoretical and practical problems to overcome before the application of gene therapy to cardiovascular di...
متن کاملProspects for gene therapy for heart failure.
Heart failure represents an enormous clinical challenge in need of effective therapeutic approaches. The possibility of gene therapy for heart failure merits consideration at this time because of improvements in vector technology; cardiac gene delivery; and, most importantly, our understanding of the molecular pathogenesis of heart failure. We will first review recent advances in cardiac gene d...
متن کاملGene therapy in heart failure.
With increasing knowledge of basic molecular mechanisms governing the development of heart failure (HF), the possibility of specifically targeting key pathological players is evolving. Technology allowing for efficient in vivo transduction of myocardial tissue with long-term expression of a transgene enables translation of basic mechanistic knowledge into potential gene therapy approaches. Gene...
متن کاملGene Therapy in Heart Failure
Gene Selection The first challenge in developing gene therapy as a treatment modality is the identification of a gene whose modification will lead to an improvement in the underlying pathophysiology that could translate into improved clinical outcomes. The expression of many hundreds of genes changes in the failing heart; some of these changes are beneficial while others confer negative effects...
متن کاملReview Gene Therapy for Heart Failure
Congestive heart failure accounts for half a million deaths per year in the United States. Despite its place among the leading causes of morbidity, pharmacological and mechanic remedies have only been able to slow the progression of the disease. Today’s science has yet to provide a cure, and there are few therapeutic modalities available for patients with advanced heart failure. There is a crit...
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ژورنال
عنوان ژورنال: Journal of Internal Medicine
سال: 2021
ISSN: 0954-6820,1365-2796
DOI: 10.1111/joim.13308